An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC 50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down.

21 Apr 2015 ANO1 antagonist, T16Ainh-A01 (A01), in the presence of a high A01. Furthermore, pain-related behaviors in mice treated with cap- saicin

For research use only. We do not sell to patients. T16AInh-A01 | C19H20N4O3S2 | CID 135460621 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities CAS: 552309-42-9: Molecular Formula: C19H20N4O3S2: Molecular Weight (g/mol) 416.514: InChI Key: QSIYTNYMBWYHAA-UHFFFAOYSA-N: Synonym: t16a inh-a01,t16ainh-a01,2-5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl thio-n-4-4-methoxyphenyl thiazol-2-yl acetamide,2-5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl thio-n-4-4-methoxyphenyl-2-thiazolyl acetamide,2-5-ethyl-4-hydroxy-6-methylpyrimidin-2 T16Ainh-A01 is a potent inhibitor of transmembrane protein 16A (TMEM16A), inhibiting TMEM16A-mediated chloride currents (IC50 of ~1 µM),and functions as a calcium-activated chloride channel (CaCC). The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications. In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+. References: TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).

800-343-7475; Contact Us; Cart T16Ainh - A01 Catalog No.GC17930: inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) Size Price Stock Qty; 5mg $30.00. The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications. In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+. References: MONNA, T16Ainh -A01, and Ani9 attenuated 5-HT/U46619-induced contractions. MONNA and T16Ainh -A01 also increased coronary flow in Langendorff perfused rat heart preparations. TMEM16A mRNA was increased in coronary artery smooth muscle cells from SHRs, and U46619 and 5-HT were more potent in arteries from SHRs than in those from normal Wistar rats.

研究T16Ainh-A01（1-30μM）对由500nM游离Ca2+诱发的IC1Ca的作用。应用. 在兔肺动脉心肌细胞中，T16Ainh-A01（1-30μM）抑制由500nM游离Ca2+激活的全细胞电流。 References: [1] Alison J Davis, et al. Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01.

The effect of pretreatment of HNECs with T16Ainh-A01, a specific inhibitor of TMEM16A, was investigated to determine if EGF-induced increase in MUC5AC expression was mediated by TMEM16A As shown in Fig. 3, pretreatment of the HNECs from CRSwNP patients with T16Ainh-A01 (10 μM) for 30 min before incubation with EGF 100 ng/ml significantly inhibited the EGF-induced increase in MUC5AC …

- Find MSDS or SDS, a COA, data sheets and more information. T16Ainh-A01 (0.3-30 μM) significantly reduces both inward and outward components of I ClCa, and inhibits I ClCa in RUICC without significantly affecting L-type Ca 2+ current.

In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+. References: [1] Alison J Davis, et al. Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01. Br …

#P < 0.05, ###P < 0.001, vs. ChemScene Provide T16Ainh-A01(CAS 552309-42-9)In-stock or Backordered impurities,Bulk custom synthesis,Formular C19H20N4O3S2,MW 416.52 bulk manufacturing, sourcing and procurement. T16Ainh-A01 is a selective inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). T16Ainh-A01 inhibits EGF-induced increases in CaCC currents, and blocks proliferation of pancreatic cancer … The effect of pretreatment of HNECs with T16Ainh-A01, a specific inhibitor of TMEM16A, was investigated to determine if EGF-induced increase in MUC5AC expression was mediated by TMEM16A As shown in Fig. 3, pretreatment of the HNECs from CRSwNP patients with T16Ainh-A01 (10 μM) for 30 min before incubation with EGF 100 ng/ml significantly inhibited the EGF-induced increase in MUC5AC … 2021-01-01 PDF | Transmembrane protein 16A was involved in the development of the monocrotaline-induced pulmonary arterial hypertension model through ERK1/2 | Find, read and cite all the research you need In contrast, T16Ainh-A01 did not alter depolarization-induced (60 mM K(+)) vasoconstriction. These data indicate that TRPC6 channels generate a local intracellular Ca(2+) signal that activates nearby ANO1 channels in myocytes to stimulate vasoconstriction. These Cl(-) currents were again potentiated with the addition of Tg, but inhibited in the presence of T16Ainh-A01. Finally, acinar cells isolated from the submandibular glands of TRPC1 knockout mice showed significant inhibition of the outward Cl(-) currents without decreasing TMEM16a expression.

T16Ainh-A01 is a potent and selective inhibitor of calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) with IC50 of Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations.
Vilken högsta lastvikt är t

CAS: 552309-42-9: Molecular Formula: C19H20N4O3S2: Molecular Weight (g/mol) 416.514: InChI Key: QSIYTNYMBWYHAA-UHFFFAOYSA-N: Synonym: t16a inh-a01,t16ainh-a01,2-5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl thio-n-4-4-methoxyphenyl thiazol-2-yl acetamide,2-5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl thio-n-4-4-methoxyphenyl-2-thiazolyl acetamide,2-5-ethyl-4-hydroxy-6-methylpyrimidin-2 T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). For research use only. We do not sell to patients.

Conclusions.
Vad är det man behöver skydda när man gör det svårt att ändra en grundlag

T16Ainh - A01 is a Ca 2+ -activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. Buy Calcium Channel inhibitor T16Ainh - A01 from AbMole BioScience.

The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications. In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+.

Stenbolaget arninge telefon

MONNA, T16Ainh -A01, and Ani9 attenuated 5-HT/U46619-induced contractions. MONNA and T16Ainh -A01 also increased coronary flow in Langendorff perfused rat heart preparations. TMEM16A mRNA was increased in coronary artery smooth muscle cells from SHRs, and U46619 and 5-HT were more potent in arteries from SHRs than in those from normal Wistar rats.

Show Size & Price TMEM16A Inhibitor, T16Ainh-A01. REACH- registreringsnummer: Det finns inget registreringsnummer för denna substans eftersom substans. C19H20N4O3S2. Tmem16ainhibitorsrevealtmem16a(t16ainh-a01). 552309-42-9. C19H20N4O3S2.

T16AInh-A01 Gene Set. From CTD Gene-Chemical Interactions. genes/proteins interacting with the chemical T16AInh-A01 from the curated CTD Gene-Chemical Interactions dataset. AR-A014418-7070 Gene Set. From CMAP Signatures of Differentially Expressed …

Anoctamin-1 and bestrophin-1 mRNA and protein were expressed in the dorsal spinal cord and DRG of naïve, sham and neuropathic rats.

- Mechanism of Action & Protocol. Background and Purpose T16Ainh‐A01 is a recently identified inhibitor of the calcium‐activated chloride channel TMEM16A. The aim of this study was to test the efficacy of T16Ainh‐A01 for inhibition T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications. In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+.